Protein Engineer

Research & Development - Geleen - WO
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Organisatie- en afdelingomschrijving

Isobionics B.V is a wholly owned subsidiary (around 15 employees) of BASF Nederland B.V. Isobionics is an ingredients company in the Netherlands that develops, produces and sells a range of natural products in the flavor and fragrance market. It does so by using its proprietary platform technology. This technology can produce many compounds such as: Compounds present in citrus oils (Lemon, Orange, Grapefruit), like Valencene and Nootkatone; important fragrance compounds present in Sandalwood oil, and many other basic building blocks for the Flavor & Fragrance industry.


Isobionics is expanding its scientific team with a Protein Engineer who will work in a challenging and highly interdisciplinary environment. Your tasks as a Protein Engineer consist of:

  • Developing and implementing approaches for the improvement of microbial strains and employing enzyme engineering.
  • Applying rational protein engineering, directed evolution and other approaches with the goal of improving enzyme expression, solubility, activity, substrate specificity and product profile.
  • Leading projects that improve the performance of microbes to produce flavor & fragrance products via fermentation.
  • In addition, you will be responsible for monitoring and evaluating scientific trends, as well as contributing to the company’s intellectual property portfolio and scientific publications.
  • You will work closely with colleagues from R&D and cooperate with external research institutions within the framework of your projects.
  • Taking up operational tasks is no problem for you.

For the position of Protein Engineer we are looking for a proactive team player with a high degree of flexibility and understanding for biotech business needs. Ideally you have strong interpersonal skills and the ability to communicate effectively with internal and external stakeholders. Furthermore you bring:

  • A PhD or master’s degree in molecular biology, biochemistry or a related discipline with several years of experience in engineering enzymes.
  • A proven track record in developing and applying protein engineering technologies for the improvement of enzymes and microbial strains.
  • Experience in the use of bioinformatics methods, protein structural analysis or modelling, modern machine learning techniques, and statistical analysis for directed evolution of enzymes.
  • Practical expertise in enzyme technologies, including protein library design and screening, enzyme kinetics, and enzyme assay development.
  • Experience in strain engineering and/or fermentation development is a plus.
  • A challenging position for preferable 40 hours a week, contract drawn up and signed with a secondment party.
  • Responsibility from day one in a challenging work environment and "on-the-job" training as part of a committed team.
  • Competitive compensation including attractive benefits as well as excellent career opportunities in an international company.
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