Strain Engineer

Research & Development - Geleen - WO
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Organisatie- en afdelingomschrijving

Isobionics B.V is a wholly owned subsidiary (around 15 employees) of BASF Nederland B.V. Isobionics is an ingredients company in the Netherlands that develops, produces and sells a range of natural products in the flavor and fragrance market. It does so by using its proprietary platform technology. This technology can produce many compounds such as: citrus oils (Lemon, Orange, Grapefruit), compounds like Valencene and Nootkatone, Sandalwood oil, Patchouli oil, … and many other less known basic building blocks for the Flavor & Fragrance industry.


Your tasks as a Strain Engineer consist of:

  • Developing and implementing approaches for the improvement of microbial strains through metabolic engineering.
  • Applying rational pathway optimization, directed evolution and other approaches with the goal of improving the fermentation productivity and yield.
  • Evaluating new techniques in strain engineering that would benefit the company.
  • Recording and presenting results clearly and effectively to the team.
  • Contributing to the company’s intellectual property portfolio and scientific publications.
  • Taking up operational tasks is not a problem for you.
  • A PhD or master’s-degree in molecular biology, biochemistry or a related discipline with several years of experience in metabolic engineering, preferably in more than one host.
  • A proven track record in developing and applying metabolic engineering techniques for the improvement of microbial strains. Previous experience with isoprenoid pathways is a plus.
  • Practical experience expertise in molecular biology techniques, including DNA assembly methods, CRISPR Cas9, pathway design, and tools for chromosomal integration.
  • Practical experience using pathway optimization tools such as RNAseq, metabolomics and proteomics is also a plus.
  • Experience with assay development and analytical techniques such as GC-MS is appreciated.
  • You thrive in a team environment, you have strong interpersonal skills and effectively collaborate with others.
  • And finally, you are self-motivated, with a high degree of flexibility and understanding of the biotech business needs.
  • A challenging position for preferable 40 hours a week, contract drawn up and signed with a secondment party.
  • Responsibility from day one in a challenging work environment and "on-the-job" training as part of a committed team.
  • Competitive compensation including attractive benefits as well as excellent career opportunities in an international company.
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